Comparative analysis of the state of erythropoesis in anemia observed in chronic diseases

Resume: The results of the work show the importance of correct assessment of erythrocyte parameters of peripheral blood, iron metabolism, EPO content and erythroid bone marrow lineage, studies of CRP, hepcidin, PRT, as diagnostic and prognostic factors in the course of the underlying disease. Criteria for the differential diagnosis of anemia in the presence of an oncological process have been formulated, the concept of "red blood coefficient" has been introduced as a new calculated hematological indicator, the significance of its use has been proved. A significant increase in the content of hemoglobin in reticulocytes, the frequency of excess CRP and the content of hepcidin in oncogynecological patients was revealed. Based on the obtained characteristics of ADS in oncogynecological pathology, revealed changes in erythrocyte parameters under the influence of anticancer therapy, a protocol for ADN treatment and recommendations for its use were developed, the effectiveness of the combined use of rh-EPO preparations and oral iron preparations in this group was proved.