Comparative analysis of the state of free radical processes in tissue of malignant and benign gastric neoplasms

The paper studies some parameters of processes of peroxide oxidation and functioning of the system of antioxidant protection (activity of catalase, superoxiddismutase, summary peroxidase activity, concentration of vitamins A and E, level of malonic dialdehyde) in bioptats of tissue of pathologic foci and perifocal zone at cancer, polyps and chronic inflammation of stomach. In 75 % of cases activity and direction of free radical processes in tissue of adenomas were identical to those observed at gastric adenocarcinomas. Disturbance of natural cascade of antioxidant enzymes SOD/catalase was a common metabolic feature for chronic inflammation and adenocarcinomas. Changes of free radical processes and functioning of the system of antioxidant protection in bioptats of gastric tissue at different pathologic states seem to be a pathogenetic moment of development of gastric cancer and indicate the disturbance of the mechanism of tissue control of proliferation in tumor tissue on the part of perifocal zone as supracellular system.