Strategies for prevention and treatment of hepatosis in dogs using DAFS-25: from theory to practice

Hepatopathies in dogs represent a significant challenge in veterinary medicine, requiring exploration of innovative therapeutic strategies. This study investigated a group of 20 dogs with various hepatopathies that underwent treatment with DAFS-25, an organoselenium compound known for its antioxidant properties. The study revealed a notable reduction in liver enzyme levels following DAFS-25 treatment: the average alanine aminotransferase (ALT) level decreased from 85 to 55 U/L, and the aspartate aminotransferase (AST) level decreased from 75 to 50 U/L. The total antioxidant capacity (TAC) in serum increased significantly from 1.2 to 2.0, indicating an enhancement in antioxidant defense mechanisms. These results underscore the hepatoprotective potential of DAFS-25, suggesting its role in reducing oxidative stress and improving hepatocellular health. Clinical observations also showed a noticeable improvement in appetite, energy levels, and overall condition of the dogs. Histopathological analysis confirmed these findings, revealing reduced liver inflammation and necrosis after treatment. Statistical analysis using paired t-tests confirmed the significance of these results, with p-values function show_eabstract() { $('#eabstract1').hide(); $('#eabstract2').show(); $('#eabstract_expand').hide(); }