Stress-induced effect of cyclophosphane and its correction with Filipendula ulmaria tincture

Stress-induced effect of cyclophosphane after its single administration to the control group of animals was shown in experimental investigations. There was evidence of decrease in the weight and sellularity of spleen and thymus, adrenal hypertrophy and ulcerous destructions in gastric rnucosa. Filipendula ulmaria tincture at a dose of 5.0 ml/kg was as a corrector of cyclophosphane. toxic effect showing the pronounced stress-protected effect. The recovery of spleen weight and cellularity, the increase in thymus weight and cellularity on days 8-11 as compared with the control group and the defense of gastric mucosa from damages were observed under the influence of alcoholic extracts from Filipendula ulmaria. Stress depth reduced by 2-6 points as compared with the control group. Thus, further investigations of extracts from Filipendula ulmaria as a corrector of cytostatic chemotherapy of tumors seem to be important.