Structural changes in the nervous system under the influence of cyclophosphamide

The work produced in 38 mongrel dogs-males. The impact of TSF - drug, with strong cytotoxic and immunosuppressive effect, causing major changes in the elements of the pyramidal, extrapyramidal systems and SEG-Manturovo of the brain. Found significant changes of morphometric parameters of nerve and glial cells. Ultrastructural indicators that exist about sudden abnormal protein synthetical and energy apparatus of the neuron. Some changes go way beyond the functional and can be interpreted as PA-tragicheskie.