Persons vaccinated against SARS-COV-2 are new kind of anticovid plasma donors

Plasma with antibodies to SARS-CoV-2 for passive immunotherapy is collected now from convalescents. We observed a cohort of 42 healthy people who received the Russian vaccine "Gam-COVID-Vac" (also known as Sputnik V), solution for intramuscular administration according to the prime-boost scheme: the introduction of component 1 was carried out on the 1st day, and component 2 - on the 21st day. Reciprocal titers of 2 antigen-specific antibodies (anti-S1 and anti-RBD) measured by two different ELISAs were monitored. We collected plasma (median - 600 ml) by apheresis on the days 21-30 from 7 donors and on the days 42-50 from 11 donors. SARS-CoV-2 S1-specific and RBD-specific IgGs were detected in 100% of our vaccinated plasma donors. All our donors were healthy and met the criteria for plasma donors. A week after donation, the median titers of both antibodies increased from 6400 to 12800. No adverse reactions were observed in donors. The prepared plasma met all generally accepted quality standards. Thus, with the introduction of vaccination against COVID-19, a new category of anti-SARS-CoV-2 plasma donors appears.