Impact of acetate-based crystalloid solutions on acid-base state and hemodynamic parameters in patients undergoing abdominal surgical operations: retrospective cohort study

Currently used balanced crystalloids vary in their composition and properties, however only spare amount of comparative data regarding their effects on different parameters of systemic homeostasis is available so far. The goal of the presented pilot retrospective observational study was to compare the effects of two frequently administered acetate-based crystalloid solutions - Sterofundin® Isotonic (group 1 ) and lonosteril® (group 2) on acid-base state and hemodynamic parameters in patients (n = 51) who underwent abdominal operations. Performed data analysis revealed no statistically significant between-group differences in pH, bicarbonate concentration, chloride and lactate levels within the whole period of monitoring. Meanwhile, differences in other acid-base parameters, namely, base excess (BE) and anion gap (AG) were statistically significant, but the clinical importance of these differences remains questionable. No significant differences in basic hemodynamic parameters were observed that serve as proof that infusion support with both crystalloids was adequate, and sustainable hemodynamic stability was provided in all patients.