Thiophane antioxidant influence on rat axial skeleton morphogenesis in the mother oxidative stress conditions

Oxidative stress development is determined on the basis of the glucocorticoid-induced oxidative stress model in the laboratory pregnant animals. It is proved by the methods of morphological and histochemical analysis that the embryo axial skeleton formation time slows in the pregnant females with high content of the free-radical lipid peroxidation products in blood plasma. Combined use of the glucocorticoids and thiophane antioxidant in gestation reduces the oxidative stress indicators in the pregnant rat blood plasma to the physiological mean level and optimizes the rat fetus axial skeleton morphogenesis.