The effect of dalarginum on the reparative regeneration of critical size calvarial defect in rats

The model of rat critical size calvarial defect in rats showed that the chronic introduction of dalarginum at 100 μg/kg in order to stimulate the δ-receptors yields a smaller increase in the percentage of mineralized bone than the combination of naloxone and dalarginum at 100 μg/kg and 0, 5 mg/kg. Comparing our data with those obtained in our previous work, we suggest that dalarginum stimulates proliferation and differentiation of osteoblast precursor cells.