The influence of phytopreparations and immunomodulators on persistent potential of microorganisms taken from the urine of the cats during infection levations of the urinary system

The objective of the study was to evaluate experimentally the effect of phytopreparations and immunomodulators used to treat carnivores with the diseases of the urinary system on persistent properties of microorganisms taken from the cats with urolithiasis and cystitis. The material was phytopreparations (stop-cystitis, cotervin, cantaren, urolex), immunomodulators (gamavit, fosprenil, roncoleukin, anandin) and 48 strains of microorganisms of different types (Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Pseudomonas aeruginosa) allocated from sick animals’ urine. The antilysozyme activity and the coefficient of biofilm formation of microorganisms were determined by photometric method, their regulation by the studied drugs was carried out by original method. It was found that phytopreparations and immunomodulators had unidirectionally reduced the antilysozyme activity and the ability of biofilm formation of staphylococci and Escherichia in vitro. Thus stop cystitis biostimulated the ability to biofilm formation in E. coli and P. aeruginosa, and urolex in E. coli. The remedies with the maximum inhibitory effect of the studied persistence factors were selected: urolex and anadin in relation to antilysozyme activity of S. aureus; cotervin - antilysozyme activity, cotervin and anandin - biofilm formation coefficient of S. epidermidis; cantaren and anadin - antilysozyme activity of E. coli; phosprenyl - antilysozyme activity of P. aeruginosa. The results presented in the study will improve the efficiency of the therapy of carnivores having the diseases of the urinary tract through using the drugs that have the maximum inhibitory activity against persistence factors of opportunistic microorganisms.