Influence of a pulse magnetic field of high voltage on the indicators of anti-aggregation activity of the chemical substance and the prepared pharmacy preparation pentoxyplin

It was found that the pharmaceutical preparation of pentoxifylline, treated with a pulsed magnetic field (PMF), changes the antiaggregatory properties. The pharmaceutical preparation contains the pure substance of pentoxifylline and a number of excipients. To understand the mechanism of changes in the antiaggregatory activity of a pharmaceutical preparation, the goal was to further investigate the effect of PMF parameters on its chemically pure substance. PMF processing was carried out on the «MIU Bio» installation with a single exposure at a field strength in the range (0.48-1.17) 106 A/m at discharge circuit frequencies (8-50) 103 Hz. Experiments have shown that the effect of PMF on the pure substance of pentoxifylline did not cause significant changes in its antiaggregatory activity. This result made it possible to get one step closer to understanding the mechanism of the effect of PMF on a given drug. Apparently, the reason for the change in the biological effectiveness of the pharmaceutical pentoxifylline treated with PMF lies in the effect of impurities, which will be the focus of further research.