Effect of intraoperative radiation therapy on lipid peroxidation and antioxidant activity in postoperative period for gastric cancer parients

Changes in antioxidant defense system were analyzed in early postoperative period for gastric cancer patients who underwent intraoperative radiation therapy (IORT). Three groups of buffer system antioxidant defense were studied: intracellular antioxidants, vitamins and albumin. The results obtained showed that lipid peroxidation (LPO) was activated after surgery in gastric cancer patients. IORT produced the enhancement of oxidative processes in postoperative period with maximum activity on day 7 after surgery. The concentration of LPO products was increasing as albumin concentration was decreasing. It is concluded from the results that administration of water- and fat-soluble antioxidants as well as of therapy aimed to maintain qualitative and quantitative levels of serum albumin is recommended for gastric cancer patients in postoperative period.