Influence of the combined use of Hypericum perforatum, Ziziphora pedicellata, Mediasia macrophylla and Glycyrrhiza glabra extracts on the development of gastropathy in rats

The experiments were conducted on 24 white male rats weighing 180-200 g, following the ethical committee's guidelines. Two variants of gastropathy were carried out: stress-induced gastric ulcer caused by immobilization, and ulcer formation induced by the administration of indomethacin. Rats in the experimental groups were orally administered dry extract intragastrically at a dose of 50 mg/kg one hour before modeling experimental ulcers. The results indicated that under immobilization stress and indomethacin administration, multiple hemorrhages were observed in all experimental rats. On the background of the combined extracts derived from medicinal plants, including Hypericum perforatum, Ziziphora pedicellata, Mediasia macrophylla, and Glycyrrhiza glabra, a significant reduction in the number of rats with ulcers and the overall number of ulcers per rat was noted.