Effects of polychemotherapy and autohemochemotherapy (combined cytostatic drug therapy according to CAP regimen) on free radical oxidation in blood plasma of rats with experimental ovarian cancer

Treatment of ovarian cancer with cytostatic drugs is usually discontinued due to profound side effects. Autohemochemotherapy reduces the toxic heart, lungs and liver damage, as well as invasive and proliferative neoplasm potential. The effect of autohemochemotherapy on free radicals in the blood plasma of the tumor-bearing organism is controversial.The main objective is to evaluate the effect of polychemotherapy and autohemochemotherapy (cytostatic drug therapy according to the CAP regimen) on free radical oxidation processes in blood plasma of rats with experimental ovarian cancer.Materials and Methods. White rats with ascites ovarian tumor (the logarithmic stage of tumor development) were treated intravenously or underwent autohemochemotherapy with cytostatic drugs according to the CAP regimen. Lipid peroxidation and oxidative modification of proteins in blood plasma were evaluated on the 3rd and 8th day after drug administration.Results. It has been established that the activation of lipid peroxidation during enzymatic depletion of the antioxidant system and carbonyl stress can be observed in the blood plasma of rats with ascites ovarian tumor both under intravenous administration and autohemochemotherapy with cytostatic drugs according to the CAP regimen...