The influence of silver nanoparticles concentration in alginate microcapsules on the realization of their effects on morphological changes in periodontitis

Objective: to evaluate the effects of alginate microcapsules on morphological changes in periodontitis depending on the concentration of silver nanoparticles in them. Material and methods. The studies were conducted on 30 rats divided into three groups of 10 animals: the comparison group - animals with an experimental model of periodontitis; experimental groups 1 and 2 - animals with periodontitis (5 weeks), which were applied to the surface of the gum gel containing microcapsules with high (0.25 M)and low (0.1 M) concentrations of silver, respectively. To assess morphological changes, the mandible was sampled with subsequent examination. Results. In animals with periodontitis, changes in the supporting apparatus of the tooth occur, including fibrillation and perivascular edema in the circular ligament of the tooth, bone resorption with its replacement with connective tissue. The application of gel containing microcapsules with silver nanoparticles leads to a partial reduction of these disorders, in particular, reduces bone resorption and its replacement by connective tissue. Destructive changes in periodontal tissues when using a gel with a high content of silver nanoparticles (0.25 M) are less pronounced than when using capsules with a low content of silver nanoparticles (0.1 M). Conclusion. Gels containing microcapsules with silver nanoparticles contribute to the reduction of destructive changes in the supporting apparatus of the tooth in periodontitis. The gel effectiveness is increases with a rise of the concentation of silver nanoparticles in alginate microcapsules.