The impact of smoking on the development of chronic obstructive pulmonary disease

Tobacco smoking is the main cause of chronic obstructive pulmonary disease. The aim of the study is to describe morphological changes in the respiratory tract under the influence of the proinflammatory effects of tobacco smoke. Smoking-induced systemic inflammation, endothelial dysfunction, and oxidative stress may contribute to the development and progression of chronic obstructive pulmonary disease.