The effect of mexidol on magnesium-calcium balance and endothelial dysfunction in operational stress

The aim of the study:to study the effect of mexidol content of ionized calcium and magnesium in erythrocytes andthe number of circulating endothelial cells in patients undergoing surgery in the maxillofacial area.Material and meth-ods.The intracellular concentration of calcium and magnesium was measured before the operation, in one, three andfive days after the surgery with the help of cytochemical method. Mexidol (100mg) was administered intravenously asa single addition to the standard premedication.Results.After surgery, the intracellular calcium and magnesium contentincreased. After 24 hours, the magnesium level began to decline, and the calcium content in erythrocytes continuedto grow. On day 5, the magnesium concentration in erythrocytes decreased below the initial level, and calcium levelsremained significantly elevated. Number of endothelial cells in the blood increased immediately after surgery andmagnesium-calcium balance and limits endothelial dysfunction. Mexidol continued growing, reaching a peak on day5 after surgery. When using mexidol decreased levels of calcium and magnesium levels help prevent falls on the 5thday after surgery, decreased the number of circulating endothelial cells.Conclusion.Mexidol prevents postoperativemagnesium violation.