Effect of melatonin on dyslipidemia factor in metabolic osteoarthritis

Introduction Osteoarthritis (OA) has long been considered from the mechanical point of view of etiology and pathogenesis, as a "wear and tear" disease. However, advances in fundamental medicine have changed the way we look at this disease. The role of systemic inflammation was determined in OA progression and risk factor related clinical phenotypes were differentiated as post-traumatic OA, age associated OA, genetic OA and metabolic syndrome associated OA. The development and progression of OA in metabolic disorders envision a concept of systemic regulation of osteocartilaginous and synovial tissues, and several studies showed that dysregulation of circadian rhythms may be involved in the development of dyslipidemia and systemic inflammation associated with obesity. The objective was to explore the effect of melatonin on the dynamics of lipid metabolism and the severity of clinical symptoms in patients with OA and insomnia based on the role of dyslipidemia in the pathogenesis of degenerative diseases. Materials and Methods The study included 36 individuals including 12 healthy volunteers and 24 inpatients of experimental groups with insomnia and Kellgren-Lawrence grades 2 and 3 gonarthrosis. Standard conservative treatment consisted of drug and physical therapy. Medical history, complaints were collected from the patients and physical examination performed to evaluate edema of the joint, alignment of the lower limb, range of motion in the joints and measure waist circumference, body height, body weight; body mass index. The biochemistry blood parameters measured included total cholesterol concentration (TCC), high-density lipoprotein cholesterol, low density lipoprotein cholesterol (LDL) and triglycerides (TG). VAS and Lequesne scale were used to assess pain and function of the joints. Results Patients with the metabolic OA showed statistically significant (p function show_eabstract() { $('#eabstract1').hide(); $('#eabstract2').show(); $('#eabstract_expand').hide(); }