Effect of melatonin on the level of DNA damage in the sperm cells of white rats

Melatonin is the hormone of pineal gland possessing wide spectrum of a biological activity has been intensively studied. It is not only transducer of circadian rhythms, but possesses a direct scavenger activity from free radicals and an indirect protective activity against cells macromolecules manifested in the regulation of gene transcription of antioxidant ferments. Also in the last few years, NER pathway of repair DNA fromt a circadian rhythm is shown. Goal of current research is to determine influence of melatonin on quantity of DNA breaks after melatonin administration at physiological concentration to intact animals. The result of study - found that melatonin may exert a protective effect at low concentrations, the administration of melatonin at night have a more pronounced protective effect. Our data indicate are non specificity protective effect of low concentrations of melatonin.