The influence of the original anticonvulsant galodif on levels of neuroactive steroid hormones - markers of stress system in patients with alcohol addiction

The article presents results of the study of influence of the original anticonvulsant galodif on levels of neuroactive steroids - markers of stress system in blood serum of patients with alcohol addiction. Increasing the ratio of the index levels of the hormone cortisol/DHEA in patients with alcoholism during abstinence significantly reduced against the background of course therapy with galodif. Increasing DHEA against the background of therapy with galodif shows stimulation of the synthesis of DHEA, providing antiglucocorticoid effect against the background of high levels of cortisol. DHEA and DHEA-S have a strong antiglucocorticoid and neuroprotective effect on the brain and can protect neurons from neurotoxicity induced by glucocorticoids. The ratio of cortisol/DHEA is of particular importance as the anti-glucocorticoid effects of DHEA lead to a decrease in anxiety and depression in humans. Increasing DHEA may increase the overall GABAergic conductivity and is a positive predictor of response to therapy with the anticonvulsant galodif.