Sex dependent of metabolic changes at laboratory animals with acute chemically induced damage of the pancreas

The aim of the study was to evaluate sex-specific metabolic changes at the laboratory animals during spontaneous recovery after a single exposure to the pancreatotoxicant - alloxan. Toxic damage of pancreas was induced by a single intraperitoneal injection of alloxan (150 mg/kg) after 18 hours of starvation. In animals of control and experimental groups 1, 3, 7, 14, 21 and 28 days after the administration of pancreotoxicant, the content of albumin, glucose, triglycerides, lactic and pyruvic acids, carboxylesterase activity, as well as the indicators of antioxidant status (malonic dialdehyde and catalase in erythrocytes, oxidase activity of ceruloplasmin) were determined in blood plasma. In experimental alloxan-induced damage of the pancreas in laboratory rats of both sexes, certain gender differences in changes in a number of biochemical parameters and antioxidant system parameters were found. The analysis of the results of the study showed that females were more sensitive to the effect of pancreatotoxicant, and normalization of the studied parameters during spontaneous recovery was slower in them than in males. The main negative effect of alloxan on the organism of females was observed on the 7th day after administration. The revealed sex differences should be taken into account when planning experimental works and explaining their results.