Effect of selective drugs that modulate the response to DNA damage on the radioresistance of Drosophila melanogaster

The search for drugs that affect the radioresistance of an organism is an urgent task of radiobiology and medicine. The effects of retinoic acid, enoxacin, KN-93, and UNC-0646 on resistance to γ-irradiation at doses of 120 and 800 Gy, as well as on the level of DNA damage and the efficiency of DNA repair were studied for the first time using the Drosophila melanogaster model. The results of the study indicate an increase in the radiosensitivity of flies after the addition of all four selective drugs to the medium at a young and mature age. Median and maximum survival after substance treatment was reduced to 50% (p