The impact of toxic substances on endocrine function of laboratory animals

Investigated the effects of mercury, chlorophos, nitrate and dioxane on the hormonal status of laboratory animals. Evaluated the impact of these drugs on the level of insulin, adrenocorticotropic hormone, triiodothyronine and thyroxine. Laboratory animals entered sopredelnymi concentrations of toxic substances. Evaluation of the results after 45 days. The research noted that all of the toxic substances in supremely concentrations lead to suppression of thyroid function. Namely, the impact of chlorophos significantly decreased production as triiodothyronine (75%) and thyroxine (37%). On the background of the use of mercury, dioxane and nitrates, as there was a decrease in the production of hormones: triiodothyronine 28%, 31% and 21%, respectively; thyroxine - 40%, 28% and 13% respectively. At the same time, noted an "explosion of activity" of the pancreas. Compared with the control group production of immunoreactive insulin. Application of chlorophos, production of the hormone increased by 5.5 times; nitrates - in 3,7 times; mercury - 8,5 times and amid dioxane - 7,9 times. Also in the control groups showed increased production of adrenocorticotropic hormone 3,8 times against use chlorophos, 2,1 times the nitrate, 3,3 - mercury and 3,7 when exposed to dioxane. Thus, on the background of application supremely concentrations of toxic substances in laboratory animals showed suppression of thyroid function, while strengthening the functions of the pituitary and pancreas.