Effect of vitamin D3 on the cytokine synthesizing activity of cells of gingival fluid

Purpose: to study the effect of vitamin D3 on cytokine activity of macrophages and monocytes of gingival fluid. Material and methods. The examination and treatment of 42 patients with chronic generalized periodontitis at the age of 45-50 years were conducted. Gingival fluid was obtained from the periodontal pockets of patients. Material processed statistically. Results. Colecalciferol efficacy in inflammation and processes of destruction of periodontal tissue was twice higher than using traditional therapy. Resistance anti-inflammatory effect of the drug was maintained for 6 months, which had been confirmed by clinical and laboratory investigations. Conclusion. The use of applications of vitamin D in the treatment of periodontitis may achieve compensatory restoration of immune protection of the oral cavity.