Impact of the natural environmental factor - trematode Opisthorchis felineus on the system of regulation of proliferative activity of somatic cells

One of the leading epigenetic factors of canerogenesis is a high level of proliferative activity of somatic cells. Activation of cholangiocyte proliferation against the background of organismal invasion by trematode Opisthorchis felineus (Rivolta, 1884) is described by many researchers. The present study shows the role of metabolites of metacercariae and opisthorchis in the induction of proliferative activity of somatic cells of the hepatobiliary system and other organs. The significance of cell-tissue bioregulators in increasing the level of proliferative activity of various tissues in trematode-infected organisms has been considered. It follows from the data obtained on the model of hepatocellular tissue that kylon-containing factor from liver tissue of healthy animals, as an inhibitor of cell-tissue proliferation, was more sensitive to hepatocytes of uninvaded inbred mice as compared to the animals invaded with the above biotic pathogen for 2 months. The level of biological activity of the studied tissue-specific effector isolated from the liver tissue of mice with the same period of opistorch invasion is lower than in the group of uninvaded animals. Hence, it follows that activation of cell-tissue proliferation in opistorch-infected animals is caused by disturbed regulation mechanisms of cell-tissue homeostasis. Decrease in the function of control over somatic cell mitotic cycle during parasitization in the hepatobiliary system of Opisthorchis felineus trematode is confirmed by increase in growth rate of syngeneic malignant tumors as well as modification of homologous leukocyte interferon effect from inhibitor of malignant process - to activator. Induction of intensive regenerative proliferation of cholangiocytes by opisthorchial metabolites as a result of dysfunction of their cell-tissue regulation mechanisms is a promoter factor of oncogenesis process.