Scope for the application of autological platelete-rich plasma (PRP) in herniology

The long-term prospects of allohernioplasty are determined by the inclusion of tissue in the frame of the mesh implant, the degree of tissue ingrowth affects the formation of relapse, and resistance to chronic infection and the return of tissue to the original structure determine the functional result. Meshes cause an acute inflammatory reaction; if it is intense – a granuloma is formed. An increase in the amount of connective tissue does not always lead to the strength of hernioplasty. The formation of coarse scar tissue is accompanied by a change in tissue elasticity, leading to wrinkling, thickening, mobility of the implant and recurrence of the hernia. Chronic pain after allohernioplasty (1–18% of patients) associated both with the surgical technique and with the presence of postoperative inflammatory complications leading to tissue fibrosis, mesh shrinkage and involvement of nerve trunks. Regulation of inflammatory cell migration into the hernia repair area defines a strategy for modulating the inflammatory response. The use of biological adhesives is accessible and effective. Fibrin glue is an expensive drug that is not reliable from the point of view of quarantine safety. Autologous platelet-rich plasma (PRP) is easier to obtain, rich in growth factors that influence cellular mechanisms, and may be a tool for improving mesh implant integration. A review of the world literature shows isolated observations on the use of PRP in experiments, so studying the mechanisms of the influence of PRP on the integration of a mesh implant into the patient’s tissue is relevant.