Newly diagnosed HIV infection in patients with progressive multifocal leukoencephalopathy (literature review and clinical cases)

In recent years, in the Kyrgyz Republic, HIV infection is more often detected at an advanced stage based on of advanced opportunistic infections. Late detection of people living with HIV causes disability and death due to untimely initiation of antiretroviral therapy and late prevention of opportunistic infections. The most difficult secondary disease to diagnose in the advanced stage of HIV infection is progressive multifocal leukoencephalopathy, often with an unfavorable outcome. This article presents two newly identified clinical cases of HIV infection in patients with difficult-to-diagnose progressive multifocal leukoencephalopathy, which may increase doctors' alertness to these diseases.