Interaction between neutrophil granulocytes and up-conversional nanoparticles in the different matrix

The LD 50 for up-conversional nanoparticles with fluorescent core Er/Yb were founded. The nanoparticles in the matrix of biogenic mineral of vitlocit are the most harmless was established. The ratio of Er and Yb has a little influence on the toxically effect of nanoparticles. The neutrophil granulocytes after interaction with up-conversional nanoparticles died by mechanism of necrosis and the energy potential of the cells remains unclaimed, as the level of glycogen after interaction with nanoparticles is not changed were established.