Importance of tumor microenvironment inflammation cells in breast cancer
Автор: Titov К.S., Grekov D.N., Zakurdaev Е.I., Lorie Z.V., Paklina О.V., Gordienko Е.N.
Журнал: Злокачественные опухоли @malignanttumors
Рубрика: Обзоры
Статья в выпуске: 1 т.14, 2024 года.
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This review evaluates the role of the tumor microenvironment of breast cancer focusing on the evidence showing that tumor-associated macrophages, neutrophils, and mast cells directly participate in tumor initiation, proliferation, and metastasizing. This study also describes microenvironment cells pathologic assessment relevant for prognostication and treatment decision. Tumor-associated macrophages stimulate breast tumor progression, including tumor cell growth, invasion and metastasizing. Tumor-associated neutrophils are more prevalent in patients with severe disease or resistance to treatment and it can be explained by their pro-tumor / immunosuppressive characteristics. The contribution of mast cells to tumor development and progression appears to be a controversial area of research. The ability of mast cells to promote angiogenesis is viewed as a key process in promoting tumor development. However, elevated level of mast cells at tumor sites seems to be connected with improved outcomes.
Breast cancer, tumor microenvironment, macrophages, neutrophils, mast cells
Короткий адрес: https://sciup.org/140305810
IDR: 140305810 | DOI: 10.18027/2224-5057-2024-14-1-67-73