Pharmacogenetics of suicide

This article examines the relationship between medication use and suicidal behavior (SB). It emphasizes that statistically documented associations between medication use and suicide are underutilized to develop hypotheses about the mechanisms underlying SB. Pharmacogenetic factors are proposed as key factors in determining the risk of druginduced SB. The need to study polymorphic genes that alter the molecular structure of drug sites of action is substantiated. This, combined with genetic and epigenetic predisposition, can lead to suicidal outcomes. The importance of informing healthcare professionals about drug side effects and reporting suspicious adverse reactions to prevent potential harm is emphasized.