Абскопальный эффект: механизм возникновения и перспективы применения в терапии метастатических форм злокачественных опухолей

Абскопальный эффект: механизм возникновения и перспективы применения в терапии метастатических форм злокачественных опухолей

Автор: Хачатурян А.В., Булычкин П.В.

Журнал: Сибирский онкологический журнал @siboncoj

Рубрика: Обзоры

Статья в выпуске: 1 т.23, 2024 года.

Бесплатный доступ

Абскопальный эффект (АЭ) в онкологической практике известен на протяжении 70 лет, однако до последнего времени его клиническая значимость была относительно невелика. Развитие препаратов ингибиторов контрольных точек иммунного ответа привело к активному изучению этого феномена. В настоящее время имеются данные об улучшении выживаемости среди пациентов, у которых регистрировался абскопальный эффект, что открывает новые перспективы лечения онкологических заболеваний различных стадий. В этом обзоре представлены сведения о механизмах абскопального эффекта, экспериментальные и клинические данные, текущие ограничения и возможные перспективы. Цель исследования - изучить современную концепцию возникновения абскопального эффекта, оценить перспективы применения в терапии метастатических форм злокачественных опухолей. Материал и методы исследования. Проведен поиск публикаций в системе Pubmed с 2010 по 2023 г., найдено 286 статей, 72 из них использованы для написания обзора.

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Абскопальный эффект, злокачественные новообразования, моноклональные антитела, лучевая терапия, иммунотерапия, иммуноопосредованный противоопухолевый ответ

Короткий адрес: https://sciup.org/140303739

IDR: 140303739   |   DOI: 10.21294/1814-4861-2024-23-1-120-129

Список литературы Абскопальный эффект: механизм возникновения и перспективы применения в терапии метастатических форм злокачественных опухолей

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