The adaptation model of cancellous bone loss for aging

The etiopathogenetic model of adaptation mechanism of cancellous bone loss with aging has been theoretically substantiated and developed on the basis of analyzing the data of the aging effect on the processes of modeling/remodeling and the mechanical properties of bone structures. The following ways of osteoporotic fracture prevention have been highlighted: working-out the methods of muscular system strengthening to preserve the quantity of mechanical signal in subjects with high risk of osteoporosis (low peak bone mass, chronic pathology, etc.), starting from 30-year age according to the principles of preventive medicine, that means from the moment when bone mass loss begins, but not after the moment when cancellous bone architecture has already been disturbed; production of medicaments to prevent bone mass loss, which would make available: 1) decrease of bone tissue mineralization with the help of osteocytic pump regulators for Ca++ washing out from bone tissue; 2) decrease of the threshold of electric impulse initiation in bone cells, that will give the possibility to optimize remodeling processes at a below level of bone tissue deformities in case of changing mechanical loads.