Adipokines and their possible role in obesity and type 2 diabetes mellitus

Автор: Kuznetsova L.A., Shpakov A.O.

Журнал: Саратовский научно-медицинский журнал @ssmj

Рубрика: Эндокринология

Статья в выпуске: 2 т.14, 2018 года.

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The adipose tissue is the endocrine organ secreting polypeptide factors, such as adipokines, which are involved in the regulation of feeding behavior, the metabolic, endocrine and inflammatory processes and insulin sensitivity. In obesity and type 2 diabetes mellitus (DM2), the production of adipokines and the activity of their signaling pathways are changed, which plays an important role in the relationship between obesity, insulin resistance and DM2. In the review (according the types of obesity) the data on the production of adipokines with diabetogenic (leptin, visfatin, chemerin, vaspin, apelin, resistin) and antidiabetic (adiponectin, omentin) properties by the adipose tissue, as well as the possible role of adipokines in the development of obesity and DM2 were discussed.

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Insulin resistance, adipokines, type 2 diabetes

Короткий адрес: https://sciup.org/149135076

IDR: 149135076

Статья научная