Агрессивный фиброматоз

Агрессивный фиброматоз

Автор: Владимирова Л.Ю., Алькина А.К.

Журнал: Злокачественные опухоли @malignanttumors

Статья в выпуске: 3S1 т.14, 2024 года.

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Агрессивный фиброматоз (АФ) или десмоидные опухоли (ДО) — это локально агрессивные и инвазивные опухоли мягких тканей мезенхимального происхождения, которые сложно лечить из‑за их вариабельных клинических проявлений, непредсказуемого клинического течения и отсутствия в настоящее время одобренных методов лечения. Это группа ЗНО редко встречается в клинической практике онколога, в связи с чем диагностика и опции лечения данной патологии существенно ограничены. На сегодняшний день, нет стандартного подхода к ведению больных с АФ, поэтому в зависимости от локализации опухоли, ее симптомов и риска развития осложнений и прогрессирования подбирается один из оптимальных методов лечения: хирургическое вмешательство или другие локальные методы, системная терапия или динамическое наблюдение. Лекарственная терапия активно развивается на протяжении последних десятилетий: от химиотерапии до внедрения тирозинкиназных ингибиторов (ТКИ) и одобрения новых молекул. В настоящее время сорафениб и пазопаниб являются одними из наиболее используемых ТКИ. Кроме того, новые ингибиторы гамма‑секретазы (нирогацестат и AL102) обещают быть эффективными средствами для лечения АФ с управляемым профилем безопасности.

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Агрессивный фиброматоз, десмоидные опухоли, ингибиторы гамма‑секретазы, ингибиторы тирозинкиназ, химиотерапия

Короткий адрес: https://sciup.org/140307166

IDR: 140307166   |   DOI: 10.18027/2224-5057-2024-14-3s1-35-41

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