Activation of expression of the ll-37 gene (antibacterial cathelicidin) via the VDR signaling pathway

This article describes current data on the mechanisms of activation of the LL-37 gene (antibacterial cathelicidin) via the VDR signaling pathway. Cathelicidin is expressed in various cells, for example, in testicular epithelial cells, skin keratinocytes, leukocytes, monocytes, neutrophils, as well as in T-, B- and NK cells. The cathelicidin molecule is multifunctional. Cathelicidin is encoded by a gene consisting of 4 exons. In humans, it is localized on chromosome 3p21.31