Activity of carboxypeptidase E under the prolonged application of neuroprotective drugs

The activity of carboxypeptidase E in the brain of rats has been measured after administration of neuroprotective drugs (piracetam, phenotropil, noopept) every 24 hours for 14 days. The prolonged application of neuroprotective drugs revealed general trends in the activity of carboxypeptidase E. Its highest activity has been recorded in the pituitary gland at 24 hours after the last injection. The following sequence of drugs in relation to the less influence on the activity of carboxypeptidase E in the pituitary gland was revealed: piracetam, fenotropil, noopept. The least activity of the enzyme studied was observed in the adrenal glands.