The activity of the nitroxidergic system in cows during estrus pharmacological stimulation

During the research it was found that the administration of prostaglandin F2a preparations increases the content of nitrogen oxide metabolites in cows. The maximum activity of the nitric oxide system is observed after 2-5 hours after the administration of estrofan preparation and decreases as its concentration in the blood decreases. The findings suggest that prostaglandin preparations are involved in the regulation of the production of nitric oxide (II) in cows. Studies on the molecular basis of the interaction between NO (II) and prostaglandins are the basis of the hypothesis that they can be considered as a target for pharmacological effects in numerous pathological conditions.