Activity of superoxide dismutase, glutathione peroxidase, glucose-6-phosphate dehydrogenase in erythrocytes of untrained rats in "to-muscular-failure" swimming test

Автор: Shadrina V.D., Vakhnina N.A., Boyko E.R.

Журнал: Ульяновский медико-биологический журнал @medbio-ulsu

Рубрика: Физиология

Статья в выпуске: 4, 2020 года.

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For an untrained organism, physical activity is physiologically stressful. The stress is accompanied by an increase in reactive oxygen intermediates. Their level in the cell is regulated by antioxidant enzymes. The aim of the paper to study the activity of superoxide dismutase (SOD), glutathione peroxidase (GP) and glucose-6-phosphate dehydrogenase (G-6-FDH) in erythrocytes under single physical load (FL) of different intensity. Materials and Methods. The authors tested male Wistar rats aged 3 months. The animals were divided into seven groups: vivarium control (VC); rats who were swimming for 60 minutes without added weight (moderate intensity load (MIL)); four groups participating in load-testing: low-intensity FL (LI) - swimming with a load of 2 % of body weight; high-intensity FL (HI) - swimming with a load of 8 %, 10 % and 15 % of body weight (HI8, HI10, HI15). Animals of the seventh group (OS) were in the shallows for 60 min without the opportunity to swim in order to induce oxidative stress without physical load. Results. In all groups, the authors observed a significant decrease in S OD activity and a significant increase in GP and G-6-FDH activity relative to VC. The greatest decrease in SOD activity was in the OS and MIL groups (by 36 % and 33.5 %, p function show_eabstract() { $('#eabstract1').hide(); $('#eabstract2').show(); $('#eabstract_expand').hide(); }


Superoxide dismutase, glutathione peroxidase, glucose-6-phosphate dehydrogenase, erythrocytes, physical load

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IDR: 14117590   |   DOI: 10.34014/2227-1848-2020-4-133-141

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