Allelic options of genes ACE, PPARG and PPARGC1A at martial artists of the city of Perm

Genotyping of 143 athletes of the martial artist at three sports schools of Perm aged from 9 up to 20 years is carried out. With use of PCR method allelic options of genes of ACE, PPARG and PPARGC1A are revealed; their frequencies and genotypes are determined. The polymorphisms of I/D of a gene of ACE (angiotensin I converting enzyme) is studied, and also a polymorphism of Pro12→Ala of a gene of PPARG (peroxisome proliferator-activated receptor gamma) and a polymorphism of Gly482Ser of a gene of PPARGC1A (peroxisome proliferator-activated receptor gamma coactivator 1-alpha) are established. Allelic options of these genes are associated with the manifestation of endurance and high-speed and power qualities at martial artists. It is established that combinations of polymorphic options of genes of ACE, PPARG and PPARGC1A affect on the success of martial artists in sports activity. The group of highly skilled athletes (Group I) authentically differs from group of low-skilled athletes (Group II) on the presence of the favourable for development of speed, force and endurance of genotypes: I/I genotype of a gene of ACE, genotype Ala/Pro of a gene of PPARG and genotypes of Gly/Gly Glu/Ser of PPARGC1A gene. On the basis of a polymorphism of three genes the integrated indicator - total genotype score (TGS) is defined. Recommendations for correction of the training process of the examined athletes are made.