Alzheimer's disease: a threat to mankind

Alzheimer's disease: a threat to mankind

Автор: Pandey Poorti, Singh Mritunjai, Gambhir I.S.

Журнал: Журнал стресс-физиологии и биохимии @jspb

Статья в выпуске: 4 т.7, 2011 года.

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Alzheimer's disease (AD) is neurodegenerative disorder common among elderly involving deficits in memory and cognition. There has been a long history of research and medical practice in AD worldwide, during which different facts came into light. During recent decades with new technologies being integrated, progress has been made in finding new genes responsible for AD, but diagnosis and treatment. In this review we will focus on molecular, genetic and other evidence underlying the known AD pathology.

Alzheimer, cholinesterase, dementia, neuritic plaques, neurofibrillary tangles

Короткий адрес: https://sciup.org/14323547

IDR: 14323547

Список литературы Alzheimer's disease: a threat to mankind

  • Abella, H.A. (2009) Report from SNM: PET imaging of brain chemistry bolsters characterization of dementias. Diagnostic Imaging, June 16, 2009.
  • Adams, R.D., Fisher, C.M., Haskim, S. et al. (1965) Symptomatic occult hydrocephalus with "normal" cerebrospinal fluid pressure. A treatable syndrome. Journal of Medicine, 273, 117-126.
  • Alzheimer's Association. (2006) Early-Onset Dementia: A National Challenge, A Future Crisis. Alzheimer's Association. Washington, D.C.
  • American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders (DSM-IV), Fourth Edition. Washington, D.C.: American Psychiatric Press 47-62.
  • Anderton, B Free radicals on the mind. Hydrogen peroxide mediates amyloid beta protein toxicity. Human Exp Toxicol 13: 719,
  • Anstey, K.J., von Sanden, C., Salim, A., O'Kearney, R. (2007) Smoking as a risk factor for dementia and cognitive decline: A meta-analysis of prospective studies. American Journal of Epidemiology; 166(4): 367-378
  • Beeri, M.S., Davidson, M., Silverman, J.M., Noy, S., Schmeidler, J., Goldbourt, U. (2005) Relationship between body height and dementia. Am J Geriatr Psychiatry; 13: 116-123.
  • Bellosta, S., Nathan, B.P., Orth, M., Dong, L.M., Mahley, R.W. Pitas, R.E. (1995) Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth. J.Biol.Chem, 270, 27063-27071
  • Biessels, G.J., Kappelle, L.J., (2005) Increased risk of Alzheimer's disease in type II diabetes: insulin resistance of the brain or insulin-induced amyloid pathology? Biochem Soc Trans. 33, 1041-1044.
  • Birkmayer, J.G., (1996) Coenzyme nicotinamide adenine dinucleotide: new therapeutic approach for improving dementia of the Alzheimer type. Ann Clin Lab Sci 26: 1-9.
  • Buttini, M., Orth, M., Bellosta, S., Akeefe, H.,Pitas, R.E., Wyss-Coray, T., Mahley, R.W.(1999) Expression ofhuman apolipoprotein E3 or E4 in the APOE -/-mice: Isoforms specific effects on neurodegeneration J. Neuroscience 19, 4867-4880
  • Calabrese, V., Butterfield, D.A., Stella, AM. (2003) Nutritional antioxidants and the heme oxygenase pathway of stress tolerance: novel targets for neuroprotection in Alzheimer's disease. Ital J Biochem; 52: 177-181.
  • Calabrese, V., Scapagnini, G., Colombrita, C., Ravagna, A., Pennisi, G., Giuffrida, Stella, A.M., Galli, F., Butterfield, D.A. (2003) Redox regulation of heat shock protein expression in aging and neurodegenerative disorders associated with oxidative stress: a nutritional approach. Amino Acids; 25: 437-444.
  • Chakraborty, C., Nandi, S., Jana, S. (2005) "Prion disease: a deadly disease for protein misfolding". C urrent Pharmaceutical Biotechnology 6 (2): 167-77.
  • Citron, M., Westaway, D., Xia, W., Carlson, G., Diehl, T., Levesque, G., Johnson-Wood K., Lee M. et al (1997) "Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice". Nat. Med. 3 (1): 67-72
  • Corder, E.H., Saunders, A.M., Strittmatter, W.J. et al. (1993) Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science; 261: 921-30.
  • Cukierman, T., Gerstein, H.C., Williamson, J.D., (2005) Cognitive decline and dementia in diabetes-a systematic overview of prospective observationalstudies. Diabetologia 42: 2460-2469.
  • Davie, C. A. (2008) A review of Parkinson's disease British Medical Bulletin; 86: 109-127
  • Decarli, C. (2004) Vascular factors in dementia: an overview. J Neurol Sci, 226: 19-23.
  • Dewji, N.N., Singer, S.J. (1996) Genetic clues to Alzheimer's disease. Science 271: 159-160.
  • Doody, R.S., Stevens, J.C., Beck, C. et al. (2001) Practice parameter: management of dementia American Academy of Neurology. Neurology 56. 1154-1166
  • Dougall, N.J., Bruggink, S., Ebmeier, K.P., (2004) "Systematic review of the diagnostic accuracy of 99mTc-HMPAO-SPECT in dementia". The American Journal of Geriatric Psychiatry 12 (6): 554-70.
  • Fadil, H., Borazanci, A., Haddou, E. A. B.,Yahyaoui, M., Korniychuk, E., Jaffe, S. L., Minagar, A. (2009). "Early Onset Dementia". International Review of Neurobiology 84: 245-262
  • Flament, S., Delacourte, A., Hemon, B., Defossez (1989) Direct biochemical evidence for an abnormal phosphorylation of tau proteins during Alzheimer disease. C.R. Acad. Sci. Paris 308, 77-82.
  • Folstein, S., Abbott, M.H., Chase, G.A., Jenses, B.A., Folstein. M.F. (1983) The association of affective disorder with Huntington's disease in a case series and in families. Psychol Med; 13: 537-542.
  • Frank, R.A., Galasko, D. et al. (2003) Biological markers for therapeutic trails in Alzheimer's disease proceedings of the biological markers working groups; NIA initiative on neuroimaging in Alzheimer's disease. Neurobiology of Aging 24: 521-536
  • Goldgaber, D., Lerman, M.I., McBride, O.W. et al: (1987) Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease. Science 235: 877-880
  • Haberland, C. (2010) "Frontotemporal dementia or frontotemporal lobar degeneration-overview of a group of proteinopathies". Ideggyogyaszati szemle 63 (3-4): 87-93
  • Hamilton, R.L. (2000) Lewy bodies in Alzheimer's disease: a neuropathological review of 145 cases using alpha-synuclein immunohistochemistry. Brain Pathol 10: 378-384.
  • Han, S.H., Hulette, C., Saunders, A.M., et al. (1994) Apolipoprotein E is present in hippocampal neurons without neurofibrillary tangles in Alzheimer's disease and age-matched controls. Exp Neurol; 128: 13-26
  • Hardy, J., Allsop, D. (1991) Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends in Pharmacological Sciences 12: 383-388.
  • Hardy, J. (2001) The genetic causes of neurodegenerative diseases. J. Alzheimer's Dis., 3, 109-116.
  • Harold, D., Abraham, R., Hollingworth, P., Sims, R., Gerrish, A., et al (2009) Genome-wide association study identifies variants in CLU and PCALM associated with Alzheimer's disease. Nature Genetics; 41(10): 1088-1093.
  • Holtzman, D.M., Pitas, R.E., Kilbridge, J., Nathan, B.P., Mahley, R.W., Bu, G. Schwartz, A.L. (1995) Low Density Lipoprotein Receptor-Related Protein Mediates Apolipoprotein E-Dependent Neurite Outgrowth in a Central Nervous System-Derived Neuronal Cell Line. Proc. Natl. Acad. Sci. USA 92, 9480-9484
  • Huang, Y., Liu, X.Q., Wyss-Coray, T., Brecht, W.J., Sanan, D.A., Mahley, R.W. (2001) Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons. Proc Natl. Acad. Sci. USA 98, 8838-8843.
  • Iqbal, K., Grundke-Iqbal, I., Smith, A.J., George, L., Tung, Y.C., Zaidi, T. (1989) Identification and localization of a tau peptide to paired helical filaments of Alzheimer disease. Proc. Natl Acad. Sci.USA, 86, 5646-5650
  • Iseki, E., Togo, T., Suzuki, K., Katsuse, O., Marui, W., de Silva, R., Lees, A., Yamamoto, T., Kosaka, K. (2003) "Dementia with Lewy bodies from the perspective of tauopathy". Acta Neuropathol. 105 (3): 265-70
  • Jellinger, K.A. (2007) The enigma of mixed dementia. Alzheimer's & Dementia; 3(1): 40-53.
  • Jellinger, K.A., Attems, J. (2007) Neuropathological evaluation of mixed dementia. Journal of Neurological Sciences 257(1-2): 80-87.
  • Joachim, C.L., Selkoe, D.J. (1992) The seminal role of beta-amyloid in the pathogenesis of Alzheimer disease. Alzheimer Dis Assoc Disord 6: 7-34,
  • Jun, G, Naj, A.C., Beecham, G.W., Wang, L.S., Buros, J., Gallins, P.J., Buxbaum, J.D. et al (2010) Meta-analysis confirm.s CR1, CLU, and PICALM as Alzheimer disease risk loci and reveals interactions with APOE genotypes. Archives of Neurology. 67(12): 1473-1484
  • Kim, M., Suh, J., Romano, D., Truong, M.H., Mullin, K. et al. (2009) Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate ?-secretase activity. Human Molecular Genetics 18(20): 3987-3996.
  • Kiraly, M.A., Kiraly, S.J. (2005) The effect of exercise on hippocampal integrity: review of recent research. Int J Psychiatry Med, 35: 75-89.
  • Kivipelto, M., Ngandu, T, Fratiglioni, L., Viitanen, M., Kareholt, I., Winblad, B., Helkala, E.L., Tuomilehto, J., Soininen, H., Nissinen, A. (2005) Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease. Arch Neurol, 62: 1556-1560.
  • Korf, E.S., Scheltens, P., Barkhof, F., de Leeuw, F.E. (2005) Blood Pressure, White Matter Lesions and Medial Temporal Lobe Atrophy: Closing the Gap between Vascular Pathology and Alzheimer's Disease? Dement Geriatr Cogn Disord, 20: 331-337.
  • Kosik, K., Greenberg, S. (1994) Tau protein and Alzheimer's disease. In Alzheimer's Disease. Raven Press, New York. 335-344.
  • Kudo, T., Iqbal, K., Ravid, R., Swaab, D.F., Grundke-Iqbal I. (1994) Alzheimer disease: correlation of cerebro-spinal fluid and brain ubiquitin levels. Brain Res 639: 1-7.
  • Lindstrom, H.A., Fritsch, T., Petot, G., Smyth, K.A., Chen, C.H., Debanne, S.M., Lerner, A.J., Friedland, R.P. (2005) The relationships between television viewing in midlife and the development of Alzheimer's disease in a case-control study. Brain Cogn, 58: 157-165.
  • Lott, I.T., Head, E. (2005) "Alzheimer disease and Down syndrome: factors in pathogenesis". Neurobiol Aging 26 (3): 383-89.
  • Lye, T.C., Shores, EA. (2000) Traumatic brain injury as a risk factor for Alzheimer's disease: A review. Neuropsychology Review, 10: 115-129.
  • Mahley, R.W. (1998) Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 240, 622-630
  • Mahley, R.W., Huang, Y., Rall, S.C., Jr., (1999) Pathogenesis of type III hyperlipoproteinemia (dysbetalipoproteinemia): questions, quandaries, and paradoxes J. lipid Res. 40, 1933-1949
  • Mahley, R.W., Rall, S.C., Jr., (2000) Apolipoprotein E: far more than a lipid transport protein. Annu. Rev. Genomics Hum. Genet. 1, 507-537
  • Mayeux, R., (1984) Behavioral manifestations of movement disorders:Parkinson's and Huntington's disease. Neurol Clin, 2: 527-540
  • Miyasaki JM, Shannon K, Voon V, Ravina B, Kleiner-Fisman G, Anderson K, et al. 2006 Practice parameter: evaluation and treatment of depression, psychosis, and dementia in Parkinson disease Neurology, 66: 996-1002.
  • Mocchegiani, E., Bertoni-Freddari, C., Marcellini, F., Malavolta, M. (2005) Brain, aging and neurodegeneration: role of zinc ion availability. Prog Neurobiol, 75: 367-390
  • Nathan, B.P., Bellosta, S., Sanan, D.A., Weisgraber, K.H., Mahley, R.W., Pitas, R.E. (1994) Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro. Science 264, 850-852
  • Newman, A.B., Fitzpatrick, A.L., Lopez, O., Jackson, S., Lyketsos, C., Jagust, W., Ives, D., Dekosky, S.T., Kuller, L.H. (2005) Dementia and Alzheimer's disease incidence in relationship to cardiovascular disease. J Am Geriatr Soc, 53: 1101-1107
  • Nishimura, M., Yu, G. and St George-Hyslop, P.H. (1999) Biology of presenilins as causative molecules for Alzheimer disease. Clin. Genet., 55, 219-225
  • Nistor, M., Don, M., Parekh, M. et al. (2007) Alpha-and beta-secretase activity as a function of age and beta-amyloid in Down syndrome and normal brain. Neurobiol Aging 28 (10): 1493-1506
  • Plassman, B.L., Langa, K.M., Fisher, G.G., Heeringa, S.G., Weir, D.R. et al. (2007) Prevalence of dementia in the United States: The Aging, Demographics, and Memory Study. Neuroepidemiology, 29 (1-2): 125-132.
  • Ravaglia, G., Forti, P., Maioli, F., Martelli, M., Servadei, L., Brunetti, N., Porcellini, E., Licastro, F. (2005) Homocysteine and folate as risk factors for dementia and Alzheimer disease. Am J Clin Nutr, 82: 636-643
  • Reisberg, B., Doody, R., Stoffler, A. et al. (2003) Memantine in moderate-to-severe Alzheimer's disease. N Engl J Med. 348: 1333-1341.
  • Roses, A.D. (1997) A model for susceptibility polymorphisms for complex diseases:apolipoprotein E and Alzheimer's disease. Neurogenetics, 1, 1-3.
  • Royall, D., Cordes, J., Polk, M. (1998) "CLOX: an executive clock drawing task". J Neurol Neurosurg Psychiatry 64 (5): 588-594.
  • Sano, M., Ernesto, C., Thomas, R.G., Klauber, M.R., Schafer, K., Grundman, M., Woodbury, P., Growdon, J., Cotman, C.W., Pfeiffer, E., Schneider, L.S., Thal, L.J. (1997) A controlled trial of selegiline, alphatocopherol, or both as treatment for Alzheimer's disease. N Engl J Med 336: 1216-1222.
  • Schellenberg, G.D. (1995) Genetic dissection of Alzheimer disease, a heterogeneous disorder. Proc. Natl Acad. Sci. USA 92, 8552-8559
  • Scott, A., Small, Duff, K. (2008) Linking A? and Tau in Late-Onset Alzheimer's Disease: A Dual Pathway Hypothesis. Neuron 60, Elsevier Inc
  • Selkoe, D.J. (1994) Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease. Annu Rev Cell Biol 10: 373-403,
  • Seshadri, S., Wolf, P.A., Beiser, A., Au, R., McNulty, K. et al. (1997) Lifetime risk of dementia and Alzheimer's disease. The impact of mortality on risk estimates in the Framingham Study. Neurology 49(6): 1498-1504
  • Shellenberg, G.D., Bird, T.D., Wijsman, E.M. et al: (1992) Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14. Science; 258: 668-671
  • Sjogren, M., Blennow, K. (2005) The link between cholesterol and Alzheimer's disease. World J Biol Psychiatry; 6: 85-97.
  • Sohal, R.S., Weindruch, R. (1996) Oxidative stress, caloric restriction, and aging. Science, 273: 59-63
  • Srinivasan, V., Pandi-Perumal, S.R., Maestroni, G.J., Esquifino, A.I., Hardeland, R., Cardinali, D.P. (2005) Role of melatonin in neurodegenerative diseases. Neurotox Res, 7: 293-318.
  • Streit, W.J. (2005) Microglia and neuroprotection: implications for Alzheimer's disease. Brain Res Brain Res Rev, 48: 234-239.
  • Strittmatter, W.J., Weisgraber, K.H., Goedert, M. et al. (1994) Hypothesis: microtubule instability and paired helical filaments formation in the Alzheimers disease brain are related to apolipoprotein E genotype. Exp Neurol, 125: 163-171.
  • Teng, E.L., Chui, H.C. (1987) "The Modified Mini-Mental State (3MS) examination". The Journal of Clinical Psychiatry 48 (8): 314-318.
  • Teng, E.L., Hasegawa, K., Homma, A. et al. (1994) The Cognitive Abilities Screening Instrument (CASI): a practical test for cross-cultural epidemiological studies of dementia. International Psychogeriatrics/IPA 6 (1): 45-58.
  • Tesseur, I., Van Dorpe, J., Bruynseels, K. Bronfman, F. Sciot, R., Van Lommel, A., Van Leuven. F. (2000) The Role of ApoE in Alzheimer's Disease: An Alternative View Am. J. Pathol. 157, 1495-1510
  • Tesseur, I., Van Dorpe, J., Spittaels, K., Van den Haute, C., Moechars, D. Van Leuven, F. (2000) Expression of human apolipoprotein E4 in neurons causes hyperphosphorylation of protein tau in the brains of transgenic mice. Am. J. Pathol. 156, 951-964
  • Thomas, P., Fenech, M. (2007) A review of genome mutation and Alzheimer's disease. Mutagenesis 22(1). 15-33.
  • Tiraboschi, P., Hansen, L.A., Thal, L.J., Corey-Bloom J. (2004) The importance of neuritic plaques and tangles to the development and evolution of AD. Neurology 62 (11): 1984-1989
  • Treiber, C. (2005) Metals on the brain. Sci Aging Knowledge Environ 36 pe27
  • Vanneste, J., Augustijn, P., Dirven, C., Tan, W.F., Goedhart, Z.D. (1992) Shunting normal-pressure hydrocephalus: do the benefits outweigh the risks? Neurology, 42(1): 54-59
  • Viswanathan, A., Rocca, W.A., Tzourio, C. (2009) Vascular risk factors and dementia: How to move forward? Neurology 72: 368-374
  • Vitaliano, P.P., Zhang, J., Scanlan, J.M. (2003) Is caregiving hazardous to one's physical health? A meta-analysis. Psychological Bulletin 129(6): 946-972.
  • Wang, G.P., Khatoon, S., Iqbal, K., Grundke-Iqbal I. (1991) Brain ubiquitin is markedly elevated in Alzheimer disease. Brain 566: 146-151.
  • Went, L.N., Vester-Van der Vlis, M., Volkers, W. et al: (1975) Early Diagnosis and Prevention of Genetic Diseases. The Netherlands: Leiden University Press; 13-25.
  • Wexler, N.S. (1979) Perceptual-motor, cognitive, and emotional characteristics of persons at risk for Huntington's disease. Adv Neurol, 23: 257-271.
  • Xu,W., Qiu, C., Gatz, M., Pedersen, N. L., Johansson, B., Fratiglioni, L. (2009) Mid-and Late-Life Diabetes in Relation to the Risk of Dementia Diabetes 58, 71-77
  • Yankner, B.A., Mesulam, M.M. (1991) Seminars in medicine of the Beth Israel Hospital, Boston. beta-Amyloid and the pathogenesis of Alzheimer's disease. N Engl J Med 325: 1849-1857
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