Ameliorative effect of aqueous-acetone extract of Raphia sudanica mesocarp on streptozotocin-induced oxidative stress and testicular damage in male Wistar rats

Background; Diabetes mellitus (DM) is a chronic metabolic disorder characterized by hyperglycemia due to defect in insulin secretion, insulin action or both. The present study aims to investigate the effects of 80% aqueous- acetone-extract of Raphia sudanica on streptozotocin induced diabetic male rats. A total of 25 adult male Wistar rats weighing between 200g and 250g were used in the study, The rats were randomly divided into 5 groups: normal control (nc), diabetic control, and diabetic rats treated orally with 100mg and 200mg kg/mg body weight. And 5mg/kg glibenclamide for 28 days. A single dose of 40mg/kg STZ was administered intraperitonially to induce diabetes. Oxidative makers, relative reproductive organ weights and sperm parameters were assessed. Results; The result revealed the presence of phytochemicals (alkaloids, phenols flavonoids, tannins, cardiac glycoside, reducing sugars, terpenoids, saponins and volatile oils while steroids were not detected). The result showed a significant p function show_abstract() { $('#abstract1').hide(); $('#abstract2').show(); $('#abstract_expand').hide(); }