Sodium aminodihydrophthalazinedione in the complex therapy of patients with alcohol dependence

Background. Chronic alcohol consumption reduces the number of innate immune cells (NK cells), weakens the body's immune defense, and impairs the effectiveness of alcohol dependence (AD) treatment. Including drugs that opti-mize immune regulation in the treatment complex is rational and justified. Objective: to study the effect of adjuvant therapy with the inclusion of sodium aminodihydrophthalazinedione in the rehabilitation complex on NK cells and clini-cal parameters of patients with alcohol dependence. Materials and Methods. At the Department of Addictive States of the Mental Health Research Institute of Tomsk National Research Medical Center, we examined 65 male patients with an ICD-10 diagnosis of “Mental and behavioral disorders due to alcohol use (dependence syndrome ‒ F10.21 and with-drawal syndrome ‒ F10.30)” with an average disease duration of 15.0±9.5 years. Patients of the main group (n=40) were prescribed the immunomodulator sodium aminodihydrophthalazinedione (Galavit®) at a dose of 100 mg/day for 10 days in addition to standard therapy on days 2-3 of treatment. Patients of the comparison group (n=25) received standard ther-apy. Clinical and biological studies were conducted dynamically: point 1 ‒ on days 2-3 of treatment, point 2 ‒ after 14-17 days of therapy. NK cell phenotyping was performed in whole blood using a BD Facs Calibur flow cytometer. To assess the clinical condition of patients, the following were used: Hospital Anxiety and Depression Scale (HADS), Quantified Scale of Comprehensive Assessment of Psychopathological Disorders in Remission (QRSOPRR), Pennsyl-vania Alcohol Craving Scale (PACS). Results. At point 1, a statistically significant decrease in the number of NK cells was observed in patients in both groups compared to the control (25 healthy men). During therapy, an increase in the number of NK cells was noted in the main group of patients at point 2 compared to point 1. The overall clinical effect was more pronounced in the main group, with the most significant being the normalization of the anxiety index. Conclu-sion. Complex treatment with the inclusion of sodium aminodihydrophthalazinedione increases the number of NK cells in the blood of patients with AD and improves the quality of remission formation, including through a reduction in anxi-ety symptoms, as well as an improvement in the general condition of patients.