Gene expression signature of radiation-induced oxidative stress in cancer cells with normal and defective TP53GENE

The aim of the present work was to find clusters of genes whose expression is repeating the radiation-induced ROS dynamics in cancer cells with mutant and normal gene TP53. It was revealed that the expression of the gene FOS depends on the intracellular concentration of ROS in irradiated cells. In TP53 mutant cells increased in FOS gene expression is accompanied by increased in GDF15 expression, whose product, protein growth differentiation factor-15 is a repressor of the FOS protein. In cells with wild-type TP53 gene the expression of GDF15 doesn’t depend from the intracellular concentration of ROS and doesn’t coordinate with the expression of the FOS gene.