Analysis of chromosomal abnormalities in benign and malignant breast tumors using comparative genomic hybridization

Chromosomal abnormalities are typical for almost all tumors, including breast cancer. The spectrum and frequency of chromosomal aberrations in breast aissues with benign (n=4) and malignant neoplasms (n=23) were investigated in 23 women using high-resolution comparative genomic hybridization. Multiple chromosomal abnormalities, including those specific to the breast cancer, were revealed in both groups. The presence of common chromosomal aberrations was found in tissues of patients with benign and malignant tumors providing evidence for a new cytogenetic marker of malignancy risk estimation. Our results indicate the possibility of application of the molecular-cytogenetic analysis in the diagnosing of chromosomal aberrations in benign tumors to predict the risk of the breast cancer.