Analysis of the effectiveness of complex rehabilitation of patients with melanoma of the skin after combined treatment: the results of the study

Introduction. Despite the wide range of complications associated with the use of antitumor therapy, patients often do not receive preventive treatment necessary to correct the consequences for the body.The purpose of the study. Analysis of the effectiveness of complex rehabilitation programs in patients with skin melanoma after combined treatment.Materials and methods. The study included 90 patients with metastatic melanoma of the skinwith a history of surgical treatment for the underlying disease; who received immunotherapy with nivolumab or pembrolizumab during the study period. The main group (n=48) included patients who underwent a comprehensive rehabilitation program. Patients who did not complete the rehabilitation program formed a control group (n=42). The effectiveness of immunotherapy was evaluated in accordance with the iRECIST 1.1 criteria. Results. Stabilization was registered in 17 (35,4%) patients of the main group and in 16 (38,1%) patients of the control group; the incidence of disease progression in both groups was comparable: 9 (18,8%) cases in the main group and 10 (23,8%) cases in the control group. Conclusion. The use of complex rehabilitation programs in the treatment of patients with melanoma demonstrates its clinical effectiveness, however, there are a number of important issues that require further resolution.