Analysis of CD3, CD68, CD163 and CK-19 expression in thymuses of neonatal children during infectious diseases

Objective: to identify the features of expression of immunohistochemical markers CD3, CD68, CD163 and CK-19 in thymus cells of neonatal children with enlarged thymus who died from infectious diseases. Material and methods. Autopsy material of children of early and late neonatal period (n=33) who died in the hospitals of Saratov city served as the material of the study. The causes of death of children were pneumonia (n=17), sepsis (n=16). Morphologic material was divided into 2 groups: Group 1 (comparison) - children whose thymus gland mass corresponded to the age norm (n=19); Group 2 (study group) - children whose thymus mass exceeded the age norm (n=14). The expression of the following markers was evaluated in the study: CD3, CD68, CD163 and CK-19.