The analysis of methylenetetrahydrofolate reductase gene polymorphism in the patients with arterial hypertension in the Republic of Mordovia

Hypertension (HTN or HT) is the main risk factor for cerebrovascular accidents and myocardial infarction, since it leads to imbalances during the vascular and thrombocytic part of hemostasis. In most cases, HTN is genetic in nature. Mutation of methylenetet-rahydrofolate (MTHFR) gene in positions C677T and A1298C is supposedly one of the major factors in evolvement of this medical condition. High percentage of patients with complicated hypertension persists in Republic of Mordovia, so the article provides data analysis of polymorphism of MTHFR gene in patients with primary hypertension of Mordvinian and Russian ethnicity residing in the Republic. Materials and Methods The study involved 113 patients (50,4 % - Mordvinian and 49,6 % - Russian nationalities) with hypertension (stages II-III in classification of Society of cardiology of Russian Federation, year 2008, BP