Analysis of the association between brain neurotrophic factor (BDNF) and chronic kidney disease (CKD) in the terminal stage

Background. The relationship between the neuromarker BDNF and various indicators in patients with CKD is relevant and poorly studied. Methodology for revealing the research problem. 150 patients with type 2 diabetes and end-stage CKD on hemodialysis were examined. Research methods included: general clinical, biochemical and instrumental studies, etc. Research results. BMI, levels of systolic and diastolic pressure and the frequency of hypertension increased significantly from group 1 to group 3, and fasting glucose and insulin levels did not differ significantly between groups. The average fasting blood BDNF values were lower in group 3 – with the most severe CCI. After the OGTT, there was a significantly significant difference in BDNF values in all groups: it decreased at 30 and 10 minutes, especially in patients with grade 3 CCI (group 3). The main finding of our study was that higher fasting serum BDNF levels were associated with a significantly lower prevalence of CKD.