Analysis of the contribution of changes in the nucleotide sequence of DNA C.C4366t MYH14 gene in ovarian cancer pathogenesis in women from Bashkortostan

Malignant neoplasms occupy the second place in mortality, second only to cardiovascular diseases. To a greater number of deaths per year than any other cancer of the reproductive system, leads to ovarian cancer (OC). In Russia, more than 14,000 new cases are diagnosed annually, half of which are fatal[1]. No more than 15% of all cases of OC can be attributed to disorders in BRCA1 / 2 genes, most of the pathology is caused by changes in other genes[2]. The search and identification of new candidate genes for OC will contribute to the early diagnosis of the disease and the creation of personalized therapy[3]. The most important genome candidate is MYH14 gene. The violation of C.C4366T (p.Q1456X) in the MYH14 gene was first detected in exomial sequencing; a high level of this protein was detected in various malignant neoplasms, including in ovarian carcinoma[4,5]. We searched for a previously unknown variant of the gene MYH14 c.C4366T for women from the Republic of Bashkortostan. As a result, it was found that the variant p.Q1456X in the MYH14 gene meets with a low frequency (0.4%) only in patients with ovarian cancer.