Endothelin receptor antagonist in the treatment of pulmonary arterial hypertension (literature review)

This analytical article provides a review of the literature for using the endothelin receptor antagonists in the treatment of pulmonary arterial hypertension. The authors discuss the use of two main drugs widely used in clinical practice: bosentan (Tracleer) and ambrisentan. Both these drugs have been registered in the Russian Federation. The article presents findings of the main clinical trials of endothelin receptor antagonists.